Direct Observation of Amyloid Fibril Formation of B 2-Microglobulin and Amyloid B Peptide
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چکیده
منابع مشابه
Amyloid Precursor Protein and Amyloid b Peptide in Human Platelets
The main component of Alzheimer’s disease (AD) senile plaques is amyloid-b peptide (Ab), a proteolytic fragment of the amyloid precursor protein (APP). Platelets contain both APP and Ab and may contribute to the perivascular amyloid deposition seen in AD. However, no data are available concerning the biochemical mechanism(s) involved in their formation and release by these cells. We found that ...
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Light chain (or AL) amyloidosis is characterized by the pathological deposition of insoluble fibrils of immunoglobulin light chain fragments in various tissues, walls of blood vessels, and basement membranes. In the present investigation, the in vitro assembly of a recombinant amyloidogenic light chain variable domain, SMA, on various surfaces was monitored using atomic force microscopy. SMA fo...
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Bakthisaran RAMAN*†, Tadato BAN†, Miyo SAKAI†, Saloni Y. PASTA*, Tangirala RAMAKRISHNA*, Hironobu NAIKI‡, Yuji GOTO†1 and Ch. Mohan RAO*1 *Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500 007, India, †Institute for Protein Research, Osaka University, and CREST, Japan Science and Technology Agency, Yamadaoka 3-2, Suita, Osaka 565–0871, Japan, and ‡Faculty of Medical Science, ...
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The lack of understanding of amyloid fibril formation at the molecular level is a major obstacle in devising strategies to interfere with the pathologies linked to peptide or protein aggregation. In particular, little is known on the role of intermediates and fibril elongation pathways as well as their dependence on the intrinsic tendency of a polypeptide chain to self-assembly by beta-sheet fo...
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We have previously shown that short peptides incorporating the sequence KLVFF can bind to the approximately 40amino acid residue Alzheimer amyloid beta-peptide (Abeta) and disrupt amyloid fibril formation (Tjernberg, L. O., Näslund, J., Lindqvist, F., Johansson, J., Karlström, A. R., Thyberg, J., Terenius, L., and Nordstedt, C. (1996) J. Biol. Chem. 271, 8545-8548). Here, it is shown that KLVFF...
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ژورنال
عنوان ژورنال: Journal of Proteomics & Bioinformatics
سال: 2008
ISSN: 0974-276X
DOI: 10.4172/jpb.s1000062